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Pam2CSK4
Item number: TGM-TP1962-1mg
Description: Toll-like receptor 2/6 (TLR2/6) agonist. Induces TNF-alpha production in human mononuclear cells. Also induces proliferation and activation of mouse splenic B cells. References: Boeglin et al (2011) Toll-like receptor agonists synergize with CD40L to induce either proliferation or plasma cell...
| CAS | 868247-72-7 |
| MW: | 1271.83 D |
815.00€
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ProTx III
Item number: TGM-TP1969-10mg
Description: Potent Nav1.7 blocker (IC50 = 2.5 nM). Also inhibits Nav1.1, Nav1.2, Nav1.3 and Nav1.6 in the nanomolar range. Exhibits no effects on Cav channels or nAChR at 5 µM. Demonstrates analgesic activity in vivo, antagonizes effects of scorpion-venom toxin OD1 at Nav1.7. References: Cardoso et al (2015)...
| MW: | 3802.41 D |
1,986.00€
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Pseudo RACK1
Item number: TGM-TP1971-1mg
Description: Activator of protein kinase C, attached to cell permeabilization Antennapedia domain vector peptide. Consists of peptide derived from the C2 domain of PKC beta linked by a disulfide bridge to the Antennapedia domain vector peptide. The Antennapedia peptide is actively taken up by intact cells, at 4 or...
| MW: | 3198.81 D |
317.00€
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OD1
Item number: TGM-TP1972-1mg
Description: Potent rat Nav1.7, human Nav1.4 and rat Nav1.6 channel activator (EC50 values are 7, 10 and 47 nM, respectively). Exhibits minimal activation at mammalian Nav1.2, Nav1.3 and Nav1.5 (EC50 values >3 µM). Inhibits fast inactivation on all channels. Increases peak currents at all voltages and stimulates a...
| MW: | 7206.1 D |
1,257.00€
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Obtustatin
Item number: TGM-TP1974-1mg
Description: Highly potent integrin alpha1beta1 inhibitor (IC50 = 0.8 nM for alpha1beta1 binding to type IV collagen). Selective for alpha1beta1 over alpha2beta1, alphaIIbbeta3, alphavbeta3, alpha4beta1, alpha5beta6, alpha9beta1 and alpha4beta7. Inhibits FGF2-stimulated angiogenesis in the chicken chorioallantoic...
| MW: | 4393.07 D |
840.00€
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Oxyntomodulin acetate
Item number: TGM-TP1976L-100mg
Description: Oxyntomodulin acetate, a 37-amino acid peptide hormone, is a glucagon-like peptide 1 (GLP-1) receptor agonist[1]. Target: Glucagon Receptor
From 174.00€
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NLS-StAx-h
Item number: TGM-TP1979-5mg
Description: Wnt inhibitor (IC50 = 1.4 µM). Stapled peptide inhibitor of oncogenic Wnt signaling. Inhibits beta-catenin-transcription factor interactions. Inhibits proliferation and migration of colorectal cancer cells. Cell permeable. References: Dietrich et al (2017) Cell permeable stapled peptide inhibitor of Wnt...
| MW: | 3445.26 D |
2,106.00€
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[Phe1Psi(CH2-NH)Gly2]Nociceptin(1-13)NH2
Item number: TGM-TP1988-1mg
Description: Potent agonist of the nociceptin (ORL1) receptor, demonstrated both in vitro and in vivo. Selective, competitive antagonism at the nociceptin receptor has also been reported (pA2 = 7.02 and 6.75 in the guinea pig ileum and mouse vas deferens respectively). References: Guerrini et al (1997) Address and...
| CAS | 213130-17-7 |
| MW: | 1367.6 D |
225.00€
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M871
Item number: TGM-TP1994-1mg
Description: Selective galanin GAL2 receptor antagonist (Ki values are 13.1 and 420 nM for GAL2 and GAL1 receptors respectively). Blocks the pro-nociceptive effect of GAL2 receptor agonists. References: Jimenez-Andrade et al (2006) Activation of peripheral galanin receptors: differential effects on nociception....
| CAS | 908844-75-7 |
| MW: | 2287.64 D |
1,450.00€
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MAIT 203
Item number: TGM-TP1995-1mg
Description: Inhibits interaction of APC and Asef (RhoGEF4). Inhibits colorectal cancer cell migration and invasion in vitro. References: Jiang et al (2017) Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration. Nat.Chem.Biol. 13 994 PMID:
| MW: | 2517.83 D |
202.00€
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MEN 11270
Item number: TGM-TP1999-5mg
Description: Peptide antagonist of the B2 bradykinin receptor (pKi = 10.3), conformationally constrained cyclized analog of HOE 140. Blocks hypotension and bronchoconstriction in vivo. Displays selectivity for B2 over 29 other receptors and ion channels (pIC50 < 5.5). References: Meini et al (1999) MEN 11270, a...
| CAS | 235082-52-7 |
| MW: | 1299.56 D |
253.00€
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Kisspeptin-54(human)
Item number: TGM-TP2005-100ug
Description: Potent endogenous ligand of the kisspeptin receptor (KISS1, GPR54). Binds with high affinity to rat and human KISS1 receptors with Ki values of 1.80 and 1.45 nM respectively. Inhibits chemotaxis, invasion and metastasis of human melanomas and breast carcinomas. Stimulates gonadotropin secretion...
| Keywords: | Metastin (human) |
| MW: | 5857.49 D |
1,355.00€
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