10Panx (trifluoroacetate salt)

10Panx is a peptide mimetic of the pannexin 1 (PANX1) ectodomain and inhibitor of PANX1, an innexin family gap domain protein and component of membrane channels. It inhibits purinergic P2X7 receptor activation-induced dye uptake, constitutive dye uptake, and hemichannel currents, as well as ATP-induced caspase activation and IL-1beta release in HEK293 cells when used at a concentration of 200 µM. 10Panx inhibits pannexin channel currents and connexin 46 channel currents in Xenopus oocytes expressing the human channels.Formal Name: L-tryptophyl-L-arginyl-L-glutaminyl-L-alanyl-L-alanyl-L-phenylalanyl-L-valyl-L-alpha-aspartyl-L-seryl-L-tyrosine, trifluoroacetate salt. Synonyms: 10Panx1, WRQAAFVDSY. Molecular Formula: C58H79N15O16 . XCF3COOH. Formula Weight: 1242.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 5 mg/ml, DMSO: 2 mg/ml, PBS (pH 7.2): 1 mg/ml. SMILES: OC(C=C1)=CC=C1C[C@@H](C(O)=O)NC([C@H](CO)NC([C@H](CC(O)=O)NC([C@H](C(C)C)NC([C@H](CC2=CC=CC=C2)NC([C@H](C)NC([C@H](C)NC([C@H](CCC(N)=O)NC([C@H](CCCNC(N)=N)NC([C@@H](N)CC3=CNC4=CC=CC=C34)=O)=O)=O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O. InChi Code: InChI=1S/C58H79N15O16.C2HF3O2/c1-29(2)47(56(87)70-42(26-46(77)78)53(84)72-44(28-74)55(86)71-43(57(88)89)24-33-16-18-35(75)19-17-33)73-54(85)41(23-32-11-6-5-7-12-32)69-49(80)31(4)65-48(79)30(3)66-51(82)40(20-21-45(60)76)68-52(83)39(15-10-22-63-58(61)62)67-50(81)37(59)25-34-27-64-38-14-9-8-13-36(34)38,3-2(4,5)1(6)7/h5-9,11-14,16-19,27,29-31,37,39-44,47,64,74-75H,10,15,20-26,28,59H2,1-4H3,(H2,60,76)(H,65,79)(H,66,82)(H,67,81)(H,68,83)(H,69,80)(H,70,87)(H,71,86)(H,72,84)(H,73,85)(H,77,78)(H,88,89)(H4,61,62,63),(H,6,7)/t30-,31-,37-,39-,40-,41-,42-,43-,44-,47-,/m0./s1. InChi Key: IUVJNMNXJXOKNR-QLTCJPIHSA-N.