Blocking Peptides

Peptide corresponding to amino acids 700 to 712 of human IRAK (1)., , Nuclear factor kappa B (NF-kB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kB mediates the expression of a great variety of genes in response to...

This peptide is used to block Jak1 Rabbit mAb #J0900-03A reactivity. Members of the Janus family of tyrosine kinases (Jak1, Jak2, Jak3 and Tyk2) are activated by ligands binding to a number of associated cytokine receptors (1). Upon cytokine receptor activation, Jak proteins become autophosphorylated and...

Peptide corresponding to amino acids 1570 to 1588 of human MADD (1). The sequence of immunogenic peptide is identical to that of DENN and differs by one amino acid with rat GDP/GTP exchange protein Rab3-GEP (2,5)., MAP kinase-activating death domain protein (MADD) was initially identified as the type 1 tumor...

Peptide corresponding to amino acids 449 to 465 of mouse FLIPL/CASHa (2,6)., , Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain (DD) containing adapter molecules and members of the ICE/CED-3 protease family....

Synthetic peptide (GAVECFEEEDSNSRESLS) corresponding to amino acids 122 to 139 of human MTBP, which differ from the mouse sequence by three amino acids (7). The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 network, including Chk2 (1),...

Location:, Peptide corresponding to amino acids 233 to 248 of human MyD88 (5), which differ from those of mouse by two amino acids. The pro-inflammatory cytokine IL-1 induced cellular response requires IL-1 receptor complex including IL-1RI and IL-1RAcP. Recently, MyD88 was identified as an adaptor molecule in the...

Peptide corresponding to amino acids 279 to 296 of human MyD88 (CTKSWFWTRLAKALSLP) (5), which are identical to those of mouse. The pro-inflammatory cytokine IL-1 induced cellular response requires IL-1 receptor complex including IL-1RI and IL-1RAcP. Recently, MyD88 was identified as an adapter molecule in the IL-1...

Peptide is used to block Neurofilament-L Rabbit mAb reactivity in immunohistochemistry protocols. The cytoskeleton consists of three types of cytosolic fibers: actin microfilaments, intermediate filaments and microtubules. Neurofilaments are the major intermediate filaments found in neurons and consist of light...

Peptide corresponding to amino acids 178 to 193 of human neurturin (1). Glial cell line-derived neurotrophic factor (GDNF) plays key roles in the control of vertebrate neuron survival and differentiation. A novel neurotrophic factor was recently cloned from human and mouse and designated neurturin (1, 2)....

Synthetic peptide (ERFGSLTMDGGLRNVD) corresponding to amino acids 712 to 727 of human NAK/TBK1 (1,2), which are identical to those of mouse homologue (1). Nuclear factor kappa B (NF-kB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and in?ammatory...

Peptide is used to block NF-kappaB p65 Rabbit mAb reactivity in immunohistochemistry protocols. Transcription factors of the nuclear factor kappaB (NF-kappaB)/Rel family play a pivotal role in inflammatory and immune responses (1,2). There are five family members in mammals: RelA, c-Rel, RelB, NF-kappaB1 (p105/p50)...

Peptide corresponding to aa931-947 of human NIK. Nuclear factor kappa B (NF-kB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kB mediates the expression of a great variety of genes in response to extracellular stimuli...