Blocking Peptides

Peptide corresponding to amino acids 83 to 97 of human eotaxin (1,2). , Chemokines play a key role in inflammation. The CC chemokine eotaxin is a potent and specific eosinophil chemoattractant that is expressed by a variety of cell types in certain inflammatory conditions (1,2). Some G-protein coupled chemokine...

Epidermal growth factor (EGF) receptor is a 170kD single-pass transmembrane tyrosine kinase. Ligand binding to this receptor results in receptor dimerization, autophosphorylation (in trans), activation of various downstream signaling molecules and lysosomal degradation (1,2). Tyrosine 845 resides in the activation...

The ezrin, radixin and moesin (ERM) proteins function as linkers between the plasma membrane and the actin cytoskeleton and are involved in cell adhesion, membrane ruffling and microvilli formation (1). ERM proteins undergo intra or intermolecular interaction between their amino- and carboxy-terminal domains,...

Peptide (DINYQDQIPRTLEE) corresponding to amino acids 609 to 622 of human F1Aa (1). This sequence is identical to the corresponding sequence of mouse FEM1b (2). Fas and tumor necrosis factor receptor 1 (TNFR1) are two prototype members in the death receptor family. A novel protein that associates with the...

Peptide (SERFQQLMKLFEKSKC) corresponding to amino acids 1253 to 1268 of human origin, which differ from those of mouse by one amino acid (1,2). A novel mammalian CED-4 homologous was recently identified and cloned in mouse (1) and human (2) and designated FLASH (for FLICE-associated huge protein). FLASH is involved...

Peptide corresponding to amino acids 2 to 18 of human FLIP2. The sequence is identical in all FLIP splice variants., Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain (DD)- containing adapter molecules and...

Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain (DD)-containing adapter molecules and members of the ICE/CED-3 protease family. Caspases-8 (FLICE) and -10 (FLICE2) are two pivotal members in the ICE/CED-3...

Control Peptide for F4550, , Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain (DD)- containing adapter molecules and members of the ICE/CED-3 protease family. Caspases-8 (FLICE) and -10 (FLICE2) are two pivotal...

Peptide corresponding to amino acids 369 to 382 of human GFRa-1 (1). This peptide is used as the immunogen for catalog no. G2033-01., , Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for central and peripheral neurons and is essential for the development of kidneys and the enteric...

Peptide corresponding to amino acids 377 to 391 of human GFRa-2. Blocking peptide for antibody catalog number: G2033-25. Members of the glial cell line-derived neurotrophic factor (GDNF) family, including GDNF and neurturin (NTN) (1), play key roles in the control of vertebrate neuron survival and differentiation....

Peptide corresponding to amino acids from 347 to 360 of murine GFRa-3 (6). Blocking peptide for catalog number: G2033-50. Members of the glial cell line-derived neurotrophic factor (GDNF) family including GDNF and neurturin (NTN) play essential roles in the control of vertebrate neuron survival and differentiation....

This peptide is used to block Phospho-GSK-3a (Ser21) Rabbit mAb #G8170-40D5 reactivity. Glycogen synthase kinase-3 (GSK-3) was initially identified as an enzyme that regulated glycogen synthesis in response to insulin (1). GSK-3 is a ubiquitously expressed serine/threonine protein kinase that phosphorylates and...