Peptides

Cathepsin C is a lysosomal cysteine protease with broad exopeptidase activity that progressively removes dipeptides from various protein and polypeptides substrates. Aside from its role in post-translational processing, cathepsins may also participate in apoptotic signaling pathways by targeting cytosolic caspases...

Q-VD-OPH is a broad-spectrum caspase inhibitor, blocking caspases-3, -7, -8, -9, -10, and -12 and inhibiting apoptosis when used at 10 µM. It more effectively inhibits apoptosis and is much less cytotoxic than Z-VAD-FMK (Cay-14463) and Boc-D-FMK (Cay-16118). Q-VD-OPH can be used in vivo, where it has been shown to...

Flagellin 22 is a peptide pathogen-associated molecular pattern (PAMP) in plants. It inhibits growth, reduces fresh weight, and increases callose levels in A. thaliana seedlings when used at a concentration of 10 µM. InChI:...

ACTH (1-4) is an N-terminal peptide fragment of adrenocorticotropic hormone (ACTH, Cay-24257). It potentiates natriuresis induced by arginine vasopressin (argipressin, Cay-24154) in cats when administered at a dose of 20 nmol/kg. Intracerebroventricular administration of ACTH (1-4) (3 µg/animal) potentiates...

[Tyr0] Fibrinopeptide A (FPA) is a synthetic peptide derivative of FPA, which is generated via. thrombin-induced cleavage of fibrinogen. [Tyr0] FPA contains a tyrosine residue preceding the FPA sequence. InChI:...

IkappaBalpha (20-39) is a peptide fragment of the N-terminal signal-receiving domain of IkappaBalpha (Cay-43691), which is an inhibitor of NF-kappaB and a member of the IkappaB family of proteins. It contains several post-translational modification sites that regulate IkappaBalpha activity, including the...

JB-1 is an insulin-like growth factor 1 receptor (IGF-1R) antagonist and a cyclic derivative of IGF-1 (60-70). It inhibits IGF-1-induced IGF-1R autophosphorylation and proliferation in BALB/c 3T3 cells overexpressing IGF-1R when used at a concentration of 1 µg/ml. Intracerebroventricular administration of JB-1 (4...

Adrenocorticotropic hormone (ACTH) (34-39) is a peptide fragment of ACTH, a peptide hormone produced by the anterior pituitary gland that is involved in the biological stress response. InChI:...

Allatostatin I is an insect neuropeptide. It is found primarily in the insect corpora allata, which are endocrine glands involved in juvenile hormone biosynthesis. Allatostatin I inhibits juvenile hormone biosynthesis in female cockroaches (D. punctata) at a variety of life stages. It reduces hindgut motility, but...

Substance P (8-11) is a peptide fragment of substance P (Cay-24035). It promotes corneal epithelial wound healing in combination with insulin-like growth factor 1 (IGF-1) in diabetic rats with streptozotocin-induced diabetes. Inner ear infusion of substance P (8-11), in combination with the IGF-1 tetrapeptide SSSR,...

Islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP) (206-214) is an autoantigenic peptide for beta-cells. It promotes mouse T cell-induced lysis of RMA-S cells expressing the MHC class I receptor in a concentration-dependent manner. IGRP (206-214) is bound in a tetramer assay by CD8+ T...

Adrenocorticotropic hormone (ACTH) (4-9) is a peptide fragment of ACTH, a peptide hormone produced by the anterior pituitary gland that is involved in the biological stress response. The amino acid sequence of ACTH (4-9) is common to ACTH and alpha- and beta-melanocyte stimulating hormones. ACTH (4-9) (50 µg/kg)...