Peptides

Human cytomegalovirus (CMV) pp65 (495-503) is an immunogenic T cell epitope derived from the CMV matrix protein 65 kDa phosphoprotein (pp65). It binds to HLA-A*0201 in a cell-free assay (IC50 = 90 nM) and induces activation of patient-derived antigen-specific CD8+ T cells. Human CMV pp65 (495-503) has been used as...

[pS345]-Chk1 (340-349) is a peptide fragment of the serine/threonine kinase checkpoint kinase 1 (Chk1) that is phosphorylated at the serine in position 345 (Ser345). Phosphorylation at Ser345 and Ser317 is involved in activation of Chk1, which results in cell cycle arrest at the S or G2/M phase. InChI:...

[D-Asp3]-Microcystin-LR is a cyanotoxin that has been found in Anabaena and an activator of nuclear factor erythroid 2-related factor 2 (Nrf2). It induces Nrf2 activation in HepG2 cells when used at concentrations ranging from 0.3-3 µM. InChI:...

TET 830-modified T helper cell epitope from tetanus toxin is an immunogenic T helper (Th) cell epitope derived from the tetanus toxin helper peptide. It increases serum levels of IgG, IgA, IL-4, and IFN-gamma in combination with self-amplifying RNA lipid nanoparticles (saLNPs) in a mouse model of severe acute...

des-(7-13) Semaglutide is a derivative of the glucagon-like peptide 1 receptor (GLP-1R) agonist semaglutide (Cay-40231, Cay-29969, Cay-40170) that does not contain amino acids 7-13, which correspond to amino acids 13-19 in GLP-1 and includes two residues important for GLP-1R interaction. InChI:...

[Glu1] Fibrinopeptide B is a synthetic peptide that corresponds to amino acids 1-14 of fibrinopeptide B with a glutamate instead of pyro-glutamine in position 1. It has been used as a model peptide and instrument control for peptide analysis by mass spectrometry (MS). InChI:...

D-Val-Leu-Lys-AMC (vLK-AMC) is a fluorogenic substrate for plasmin. Upon enzymatic cleavage by plasmin, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify plasmin activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively. vLK-AMC has been used to...

L-Lys(Ac)-OH is an acetylated form of L-lysine (Cay-36455). It is increased in the plasma of patients with primary biliary cholangitis- or primary sclerosing cholangitis-associated liver cirrhosis and is correlated with disease severity. InChI:...

Survodutide is a peptide agonist of the glucagon receptor (GCGR) and glucagon-like peptide 1 receptor (GLP-1R). It induces cAMP production in CHO-K1 cells expressing human GCGR or GLP-1R (EC50s = 0.52 and 0.33 nM, respectively). In vivo, survodutide (30 and 100 nmol/kg) reduces food intake in wild-type but not...

DNA polymerase alpha subunit B (POLA2) (22-30) is a peptide fragment of POLA2, which is a protein member of DNA polymerase alpha and involved in initiating DNA replication and DNA double-strand break (DSB) repair. InChI:...

Preferentially expressed antigen in melanoma (PRAME) (425-433) is an immunogenic T cell epitope. It binds to HLA-A*0201-positive JY B lymphoblastoid cells with an IC50 value of 3.7 µM. Co-culture of PRAME (425-433)-primed isolated human HLA-A*0201-positive antigen-presenting cells with naïve autologous CD8+ T cells...

Spindle pole body component 25 (SPC25) peptide is a peptide fragment of SPC25, which is a protein member of the NDC80 kinetochore complex and an effector of kinetochore-microtubule attachment during cell division. InChI:...