Peptides

RHAU 23 is a peptide fragment of RNA helicase associated with AU-rich element protein (RHAU). RHAU peptide fragments have been incorporated into peptide-peptide nucleic acid (PNA) conjugates and detection and pull-down probes to stabilize bimolecular guanine-quadruplexes (G4s) and capture G4 structures in vitro,...

Cyclic citrullinated peptide (CCP) is a cyclic peptide that corresponds to amino acids 447-468 of human filaggrin but contains Q447H, S449C, G459R, E460G, S462C, and S468K substitutions and is citrullinated at arginine 455. This product can be used in the detection of anti-citrulline autoantibodies. Formal Name:...

Non-citrullinated peptide (NCP) is a cyclic peptide that corresponds to amino acids 447-468 of human filaggrin but contains Q447H, S449C, G459R, E460G, S462C, and S468K substitutions. This product can be used as a negative control in the detection of anti-citrulline autoantibodies and is the non-citrullinated...

6x-His is a polyhistidine peptide tag. It has been used in various applications, including affinity purification, addition to the sequences of recombinant proteins to selectively pull-down those proteins, and structural biology applications. Formal Name:...

LAT (phospho-Tyr132)-biotin peptide is a biotinylated peptide corresponding to amino acids 125 to 140 or 154 to 169 of the short and long splice variants, respectively, of linker for activation of T cells (LAT). LAT is a transmembrane adaptor protein that is subject to phosphorylation at Tyr132/Tyr161 by...

(BOC-VPR)2R110 is a sentive fluorogenic substrate for alpha-thrombin. The non-fluorescent substrate generates a bright green fluorescent R110 product that has Ex/Em = 495/520 nm, and can be easily detected with the FITC filter set. This substrate has also been used for the rapid detection of MRSA...

Z-VAD(OMe)-FMK is a cell-permeable, competitive, and irreversible inhibitor of all caspases. Through this action, it inhibits cleavage of poly(ADP-ribose) polymerase, preventing apoptosis when used at 10-50 µM. It also blocks caspase-mediated apoptosis in vivo. Z-VAD(OMe)-FMK effectively prevents caspase action in...

Proteinase 3 (PR3, myeloblastin) is a polymorphonuclear leukocyte serine proteinase that degrades matrix proteins including fibronectin, laminin, vitronectin, and collagen type IV to generate antimicrobial peptides. Neutrophil elastase is a serine proteinase that is secreted by neutrophils during inflammation to...

Peptide YY (PYY) is a polypeptide that is released postprandially in proportion to meal energy content by endocrine L cells in the ileum and colon in order to regulate appetite. PYY, along with neuropeptide Y (NPY, Cay-15071), inhibits gastrointestinal motility and electrolyte secretion, which is thought to indicate...

The non-fluorescent R110 substrates generate the bright green fluorescent rhodamine 110 product that has Ex/Em = 494/521 nm, and can be easily detected with a FITC filter set. In general, R110 substrates are much more sensitive than the AMC-, AFC- or 4-nitroaniline-based substrates. This R110 substrate is used for...

Synthetic. Soluble in aqueous solution (5% AcOH) (1mg/ml). Glucagon-like peptide-1 (GLP-1) receptor agonist. Antidiabetic agent against type 2 diabetes (T2D). Stimulates insulin and suppresses glucagon secretion in a glucose-dependent manner. Longer-acting alternative to liraglutide. Chemically similar to...

Bortezomib is a dipeptide boronic acid derivative that reversibly inhibits the 20S proteasome (Ki = 0.6 nM). It binds the beta5-subunit of the 20S proteasome and selectively inhibits chymotryptic activity. In part by blocking the degradation of tumor-suppressing and proapoptotic proteins, bortezomib drives cell...