Peptides

Oligopeptide-41 is a cosmeceutical peptide. It corresponds to amino acids 152-164 of human FGF7. Formulations containing oligopeptide-41 have been used in hair care products.. SMILES:...

Kyotorphin is an endogenous analgesic neuropeptide found in mammalian brain and cerebrospinal fluid (CSF). It binds to the kyotorphin receptor with Kd values of 0.34 and 9.07 nM for the high- and low-affinity binding sites, respectively, in rat brain membranes. Kyotorphin (10 µM) induces the release of...

HAP-1 is a synovial fibroblast-targeting peptide. It has been conjugated to the antimicrobial peptide (KLAK)2 to generate a pro-apoptotic peptide, which decreases synovial leukocyte infiltration in a rabbit model of rheumatoid arthritis when administered intra-articularly. HAP-1 has also been conjugated to liposomes...

Dipeptide 2 is an inhibitor of angiotensin-converting enzyme (ACE, IC50 = 1.4 µM). It reduces systolic blood pressure in spontaneously hypertensive rats at 100 mg/kg. Formulations containing dipeptide 2 have been used in cosmetics and skin care products.. SMILES: CC(C)[C@H](N)C(N[C@H](C(O)=O)CC1=CNC2=CC=CC=C12)=O....

H-Ala-Glu-Asp-OH (AED) is a synthetic tripeptide with geroprotective effects in vitro. It increases proliferation and reduces apoptosis in young and aged rat skin fibroblast cultures but reduces matrix metalloproteinase-9 (MMP-9) levels only in young cultures. AED (20 ng/ml) increases sirtuin 1 (SIRT1), SIRT6, and...

LDV-K(azide) is a functionalized peptide containing an LDV motif for binding integrin alpha4beta1 and a modified version of LDV-azide. LDV-K(azide) can be conjugated to alkyne-containing molecules via click chemistry.. SMILES:...

Xenin-25 is an endogenous peptide and a neurotensin (NTS) receptor ligand. It binds to NTS receptors in HEK293 cell membranes expressing the mouse receptor. It is expressed in K cells in the small intestine and co-secreted with glucose-dependent insulinotropic polypeptide (GIP). Xenin-25 (1 µM) stimulates the...

H-L-Cys(MDNPE)-OH is a photocleavable derivative of the amino acid L-cysteine (Cay33309). Upon irradiation at 365 nm, L-cysteine is released. H-L-Cys(MDNPE)-OH has been used for site-specific caged cysteine incorporation in proteins in E. coli and HEK293T cells.. SMILES:...

Cholecystokinin (CCK) octapeptide is a peptide hormone found in the intestine and brain that stimulates digestion, mediates satiety, and is involved in anxiety. It is a cleavage product of the full CCK preprohormone. CCK octapeptide (non-sulfated) has 1/300th of the activity of sulfated CCK octapeptide.Formal Name:...

DC-2 peptide is a synthetic peptide that contains a DHHC palmitoylation motif. It reduces H-Ras cell membrane localization in HeLa cells and increases ERK and Akt phosphorylation in SW480 colorectal cancer cells with high EGFR expression but not in SW620 colorectal cancer cells with low EGFR expression. DC-2 reduces...

TX0121 is a peptide corresponding to amino acids 201-209 of centromere protein I (CENP-1).. SMILES:...

TX0136 is a peptide corresponding to amino acids 196-204 of centromere protein I (CENP-1).. SMILES: C[C@@H](C(N[C@H](C(N[C@@H](CS[H])C(N1CCC[C@H]1C(N[C@@H](CC2=CC=C(O[H])C=C2)C(N[C@@H](C(C)C)C(N[C@@H](CS[H])C(N[C@@H](CC3=CN([H])C=N3)C(N[C@H](C(O)=O)CC(C)C)=O)=O)=O)=O)=O)=O)=O)CC(C)C)=O)N[H].O=C(O)C(F)(F)F. InChi...