Peptides

Retatrutide (LY3437943) is a triple agonist peptide of the glucagon receptor (GCGR), glucosedependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R) of interest in the treatment of obesity.

Exendin-4 (Exenatide), a 39 amino acid peptide, is a long-acting GLP-1 ( glucagon-like peptide-1) receptor agonist that promotes insluin secretion, and of potential use in the treatment of MASH.

Lixisenatide is a GLP-1 (glucagon-like peptide-1) receptor agonist used in the treatment of type 2 diabetes (T2D). Lixisenatide inhibits the inflammatory response through down regulation of proinflammatory cytokines, and blocks of cellular signaling pathways.

Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist. Semaglutide is used in the treatment of type 2 diabetes (T2D) and obesity.

Description: Fmoc-Ser(tBu)-Ser(psi(Me,Me)pro)-OH is an amino acid derivative with diverse applications in life science research. Smiles: CC(C)(C)OC[C@H](NC(=O)OCC1c2ccccc2-c2ccccc12)C(=O)N1[C@@H](COC1(C)C)C(O)=O

Description: Fmoc-Ser(tBu)-Thr(psi(Me,Me)pro)-OH is a valuable organic compound for life sciences research [Catalog number: T67193, CAS number: 1266350-99-5]. Smiles: C[C@H]1OC(C)(C)N([C@@H]1C(O)=O)C(=O)[C@H](COC(C)(C)C)NC(=O)OCC1c2ccccc2-c2ccccc12

Description: CXCR4 antagonist 4 is an orally active and potent CXCR4 antagonist with an IC50 of 24 nM. CXCR4 antagonist 4 inhibits CYP 2D6 activity, increases PAMPA permeability, and effectively blocks entry of human immunodeficiency virus (IC50=7 nM).

Description: CHIKV-IN-3 is a potent inhibitor effective against two low-passage CHIKV strains, with EC50 values of 1.55 µM for CHIKV-122508 and 0.14 µM for CHIKV-6708, respectively. It targets host cells to disrupt viral replication while maintaining minimal cytotoxic liability (CC50 > 100 µM). Additionally,...

GIP (gastric inhibitory polypeptide), also known as glucose-dependent insulinitropic polypeptide, is an incretin hormone involved in insulin secretion from pancreatic beta cells in response to food ingestion.

GLP-1(7-37) is a truncated form of GLP-1 (glucagon-like peptide-1), due to posttranslational processing of the proglucagon peptide in the intestinal L-cells. It is an insulinotropic hormone, playing a crucial role in insulin secretion.

GLP-1 (7-36) amide is a GLP-1 (glucagon-like peptide-1) is the GLP-1 secreted peptide. It acts on insulin secretion, glucagon secretion and can reduce gastric emptying. It is secreted by the L-cels of the intestinal mucosa and it is degraded by DPP-IV (dipeptidyl-peptidase-IV).

Exedin (9-39) is a GLP-1 (glucagon-like peptide-1) receptor competitive antagonist, with effects on glucose levels.