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Z-VRPR-FMK trifluoroacetate salt
Item number: TGM-TP2101-100mg
Description: Irreversible MALT1 inhibitor. Suppresses T cell activation-induced cleavage of Bcl-10 in a dose-dependent manor. Reduces Jurkat cell adhesion to fibronectin. Cell permeable. References: Rebeaud et al (2008) The proteolytic activity of the paracaspase MALT1 is key in T cell activation. Nat.Immunol. 9 272...
| MW: | 790.81 D |
Please request pricing for this article.
WL 47 - dimer
Item number: TGM-TP2102-10mg
Description: High affinity caveolin-1 (CAV1) ligand (Kd = 23 nM), disrupts caveolin-1 oligomers. Exhibits selectivity for CAV1 over BSA, casein and HEWL. References: Gilliam et al (2016) Affinity-Guided Design of Caveolin-1 Ligands for Deoligomerization. J.Med.Chem. 59 4019 PMID:
| MW: | 1844.3 D |
315.00€
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TAPI 0
Item number: TGM-TP2107-1mg
Description: ADAM-17 (TACE) and MMP inhibitor, attenuates TNF-alpha processing. Acts in concert with GM6001 to inhibit Chlamydia trachomatis growth. References: Balakrishnan et al (2006) Metalloprotease inhibitors GM6001 and TAPI-0 inhibit the obligate intracellular human pathogen Chlamydia trachomatis by targeting...
| CAS | 163958-73-4 |
| MW: | 456.54 D |
1,222.00€
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TAPI 2
Item number: TGM-TP2108-1mg
Description: ADAM-17 (TACE) and MMP inhibitor (Ki = 120 nM at ADAM-17). Sensitizes cancer stem cells to the lethal effects of 5-FU in vitro. Blocks shedding of TNF-alpha from cell membranes. References: Moss et al (2007) Fluorescent substrates for the proteinases ADAM17, ADAM10, ADAM8, and ADAM12 useful for...
| CAS | 689284-12-6 |
| MW: | 415.54 D |
1,222.00€
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Tertiapin LQ
Item number: TGM-TP2113-10mg
Description: Blocker of Kir1.1 channels, displays >250-fold selectivity for Kir1.1 (Kd values are 1.1, 274 and 361 nM for Kir1.1, Kir3.1/3.2 and Kir3.1/3.4 respectively). Derivative of tertiapin-Q. References: Ramu et al (2008) Engineered specific and high-affinity inhibitor for a subtype of inward-rectifier K+...
| MW: | 2428.03 D |
475.00€
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Tertiapin-Q acetate
Item number: TGM-TP2114L-100mg
Description: Tertiapin-Q acetate is a bee toxin derivative that inhibits BK-type K(+) channels in a concentration-dependent manner and inhibits efflux to K(+). Target: Potassium Channel. Smiles:...
| Keywords: | Tertiapin-Q acetate(910044-56-3 Free base) |
| MW: | 2512.06 D |
From 139.00€
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SAH-EZH2
Item number: TGM-TP2115-5mg
Description: EZH2/EPP interaction inhibitor (Kd = 320 nM). Suppresses EZH2 expression and H3K27 trimethylation by PCR2 complex. Arrests proliferation and induces monocyte to macrophage differentiation of MLL-AF9 leukemia cell line. References: Kim et al (2013) Targeted disruption of the EZH2-EED complex inhibits...
| CAS | 1453222-26-8 |
| MW: | 3432.05 D |
1,320.00€
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Sarafotoxin S6c
Item number: TGM-TP2120-100ug
Description: Highly selective ETB endothelin receptor agonist (Ki values are 0.29 and 28000 nM at ETB and ETA receptors respectively). References: Matsuo et al (1997) Effects of sarafotoxin S6c on antidiuresis and NE overflow induced by stimulation of renal nerves in anesthetized dogs. J.Pharmacol.Exp.Ther. 280 905...
| MW: | 2516 D |
885.00€
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Seglitide
Item number: TGM-TP2122-1mg
Description: Peptide agonist for sst2 and sst5 somatostatin receptors. IC50/Kd values (nM) at cloned human somatostatin receptors are: > 1000 (sst1), 0.2 - 1.5 (sst2), 27 - 36 (sst3), > 127 (sst4), and 0.06 - 23 (sst5). References: Hoyer et al (1994) Molecular pharmacology of somatostatin receptors. Naunyn...
| CAS | 81377-02-8 |
| MW: | 808.98 D |
220.00€
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Somatostatin 1-28
Item number: TGM-TP2124-500ug
Description: Somatostatin receptor agonist, derived from the post-translational cleavage of prosomatostatin. References: Panetta et al (1994) Molecular cloning, functional characterization and chromosomal localization of a human somatostatin receptor (somatostatin receptor type 5) with preferential affinity for...
| MW: | 3149 D |
1,355.00€
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R 892
Item number: TGM-TP2126-1mg
Description: Potent and selective bradykinin B1 receptor antagonist (ID50 values are 2.8 and > 600 nM at B1 and B2 receptors respectively). Exhibits no intrinsic agonist activity and is resistant to aminopeptidase and kininase II (ACE) cleavage. Displays hypertensive activity in vivo. References: Gobeil et al (1996)...
| CAS | 229030-05-1 |
| MW: | 1154.37 D |
170.00€
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RI-STAD 2
Item number: TGM-TP2129-10mg
Description: AKAP disruptor. Selectively binds PKA-RI with high affinity (KD values are 6.2 and 12.1 nM for the RIalpha and beta subunits, respectively) and blocks its interaction with AKAP. Inhibits type I PKA-mediated phosphorylation in live cells. Cell permeable. References: Wang et al (2015) PKA-type I selective...
| MW: | 2401.75 D |
1,646.00€
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