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Cortagine
Item number: TGM-TP2067-1mg
Description: Potent and selective corticotrophin releasing factor receptor 1 (CRF1) agonist (EC50 = 0.18 nM for rat CRF1). Displays anxiolytic and antidepressant activity in vivo. Microinfusion into mouse prefrontal cortex reduces defensive behavior in vivo. References: Tezval et al (2004) Cortagine, a specific...
| MW: | 4442.06 D |
330.00€
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BDNF (human)
Item number: TGM-TP2069-10ug
Description: Member of the neurotrophin growth factor family that binds and activates TrkB and p75 neurotrophin receptors. Enhances the survival, growth and differentiation of neurons. BDNF expression is altered in neurodegenerative disorders such as Parkinson's and Alzheimer's disease. References: Lipsky and Marini...
| MW: | 26984 D |
1,450.00€
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BDS I
Item number: TGM-TP2070-10mg
Description: Potent and reversible Kv3.4 potassium channel blocker (IC50 = 47 nM), also attenuates inactivation of sodium currents by acting on Nav1.7 and Nav1.3 channels. Enhances TTX-sensitive sodium currents in rat small dorsal root ganglion neurons. Neuroprotective. References: Diochot et al (1998) Sea anemone...
| MW: | 4708.37 D |
2,741.00€
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Bay 55-9837 acetate
Item number: TGM-TP2071L-100mg
Description: Bay 55-9837 acetate is a potent and highly selective VPAC2 agonist(Kd = 0.65 nM) and can be used in type 2 diabetes studies. Target: Glucagon Receptor. References: Tsutsumi M, et, al. A potent and highly selective VPAC2 agonist enhances glucose-induced insulin release and glucose disposal: a potential...
From 304.00€
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Bombinakinin M
Item number: TGM-TP2075-1mg
Description: Potent bradykinin receptor agonist. Highly selective for mammalian arterial smooth muscle bradykinin receptors, displaying ~ 50-fold greater potency than bradykinin. Elicits dose-dependent contractile effects in smooth muscle of guinea pig ileum (EC50 = 4.0 nM). References: Lai et al (2001) A novel...
| CAS | 509151-65-9 |
| MW: | 2179.55 D |
217.00€
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[Phe8Psi(CH-NH)-Arg9]-Bradykinin
Item number: TGM-TP2076-1mg
Description: Selective bradykinin B2 receptor agonist that is resistant to carboxypeptidase cleavage. 5-fold more potent and exhibits a more prolonged duration of action than bradykinin in vivo. References: Drapeau et al (1988) [Phe8Psi(CH2-NH)Arg9]bradykinin, a B2 receptor selective agonist which is not broken down...
| CAS | 118122-39-7 |
| MW: | 1046.23 D |
223.00€
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ADWX 1
Item number: TGM-TP2080-10mg
Description: Potent and selective KV1.3 channel blocker (IC50 values are 0.0019 and 0.65 nM for KV1.3 and KV1.1, respectively). Inhibits CD4+ CCR7- T cell activation. Ameliorates rat experimental autoimmune encephalomyelitis, in a model for multiple sclerosis. References: Han et al (2008) Structural basis of a...
| MW: | 4071.86 D |
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N-Acetyl-O-phosphono-Tyr-Glu Dipentylamide
Item number: TGM-TP2084-10mg
Description: Phosphopeptide, binds to the src SH2 domain. References: Charifson et al (1997) Peptide ligands of pp60(c-src) SH2 domains: a thermodynamic and structural study. Biochemistry 36 6283 PMID:
| CAS | 190078-50-3 |
| MW: | 571.61 D |
195.00€
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AdTx1
Item number: TGM-TP2086-1mg
Description: Selective, high affinity, non-competitive alpha1A adrenoceptor antagonist (Ki = 0.35 nM). Exhibits no significant activity against a range of other GPCRs, including alpha2A, beta1 and beta2 adrenoceptors. Antagonizes effects of phenylephrine on isolated rabbit prostate muscle in vitro and on...
| MW: | 7283.22 D |
1,586.00€
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AmmTX3
Item number: TGM-TP2090-5mg
Description: KV4 channel blocker. Blocks A-type K+ current (ISA) in mouse cerebellar granule neurons. The accessory dipeptidyl peptidase-like proteins (DPP) 6 and 10 are required for blockade. References: Maffie et al (2013) Dipeptidyl-peptidase-like-proteins confer high sensitivity to the scorpion toxin AmmTX3 to...
| MW: | 3822.47 D |
2,256.00€
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Astressin 2B
Item number: TGM-TP2095-500ug
Description: Potent and selective corticotropin-releasing factor receptor 2 (CRF2) antagonist (IC50 values are 1.3 and > 500 nM for CRF2 and CRF1 respectively). Antagonizes CRF2-mediated inhibition of gastric emptying. References: Rivier et al (2002) Potent and long-acting cortico. releasing factor (CRF) receptor 2...
| MW: | 4041.69 D |
1,858.00€
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[Ala1,3,11,15]-Endothelin
Item number: TGM-TP2099-5mg
Description: Selective ETB endothelin receptor agonist (IC50 values are 0.33 and 2200 nM for displacing [125I]-ET-1 from ETB and ETA receptors respectively). References: Nakamichi et al (1992) Different distribution of endothelin receptor subtypes in pulmonary tissues revealed by the novel selective ligands BQ-123...
| CAS | 121204-87-3 |
| MW: | 2368 D |
475.00€
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