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ICI 174,864
Item number: TGM-TP2013-1mg
Description: Selective delta opioid antagonist. Exhibits partial agonist in vitro activity at delta receptors at high concentrations. References: Cohen et al (1996) Opioid agonist activity of ICI 174864 and its carboxypeptidase degradation product, LY281217. J.Pharmacol.Exp.Ther. 238 769 PMID:
| CAS | 89352-67-0 |
| MW: | 691.87 D |
674.00€
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GIP (1-39)
Item number: TGM-TP2017-1mg
Description: Endogenous truncated form of the incretin hormone GIP. More potent at stimulating glucose-dependent insulin secretion from rat pancreatic beta-cells than GIP. References: Xie et al (2004) GIP1-39, a novel Insotropic peptide form and aspects on its mechanism of action. Regul.Peptides 121 107
| CAS | 725474-97-5 |
| MW: | 4633.21 D |
1,592.00€
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[D-Ala2]-GIP (human)
Item number: TGM-TP2019-1mg
Description: Highly potent GIP receptor agonist (EC50 = 630 ± 119 pM). Displays equivalent cAMP stimulating properties and improved resistance to enzymatic degradation compared to native GIP in cells expressing wild type GIP receptor. Improves glucose tolerance, insulin release and cognitive function in various...
| CAS | 444073-04-5 |
| MW: | 4983.58 D |
1,592.00€
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[Pro3]-GIP (Mouse)
Item number: TGM-TP2020-5mg
Description: GIP receptor antagonist (IC50 = 2.6µM). Inhibits GIP-stimulated insulin release from pancreatic beta cells in vitro. In ob/ob mice, blocks the effects of GIP on insulin release and plasma glucose levels. Also improves intraperitoneal glucose tolerance, insulin sensitivity, and glucose response to...
| MW: | 4971.62 D |
387.00€
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[Pro3]-GIP (Rat)
Item number: TGM-TP2021-5mg
Description: High affinity rat GIP receptor partial agonist (Kd = 13 nM). Increases cAMP accumulation in COS-7 cells transfected with rat GIP receptor, while also acting as a competitive antagonist of GIP. References: Sparre-Ulrich et al (2016) Species-specific action of (Pro3)GIP - a full agonist at human GIP...
| MW: | 4970.63 D |
387.00€
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GRP (porcine)
Item number: TGM-TP2026-1mg
Description: Mammalian bombesin-like peptide neurotransmitter that is an agonist for the gastrin-releasing peptide receptor (GRPR). GRP has been reported to activate GABAergic interneurons in the amygdala leading to increased GABA release and fear suppression in mice in vivo. Also involved in mitogenesis, and GI...
| CAS | 74815-57-9 |
| MW: | 2805.31 D |
237.00€
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Z-DQMD-FMK
Item number: TGM-TP2037-1mg
Description: Caspase-3 inhibitor. Inhibits MG 132-induced small cell lung cancer cell death in vitro. References: Izban et al (2001) Characterization of NF-kappaB expression in Hodgkin's disease: inhibition of constitutively expressed NF-kappaB results in spontaneous caspase-independent apoptosis in Hodgkin and...
| CAS | 767287-99-0 |
| MW: | 685.72 D |
307.00€
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Dynamin inhibitory peptide, myristoylated (control)
Item number: TGM-TP2039-1mg
Description: Control peptide version of dynamin inhibitory peptide, myristoylated, an inhibitor of the GTPase dynamin that competitively blocks binding of dynamin to amphiphysin, preventing endocytosis. In contrast to dynamin inhibitory peptide, has no significant effect on GABAA receptor-mediated miniature IPSPs....
| MW: | 1330.64 D |
338.00€
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C 21
Item number: TGM-TP2041-1mg
Description: Selective protein arginine methyltransferase 1 (PRMT1) inhibitor (IC50 = 1.8 µM). Exhibits five-fold selectivity for PRMT1 over PRMT6 and >250-fold selectivity over PRMT3 and CARM1. References: Obianyo et al (2010) A chloroacetamidine-based inactivator of protein arginine methyltransferase 1: design,...
| CAS | 1229236-78-5 |
| MW: | 2166.94 D |
286.00€
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CRSP-1
Item number: TGM-TP2049-1mg
Description: Endogenous central calcitonin (CT) receptor agonist that stimulates cAMP formation at a potency 350-fold greater than CT (ED50 values are 0.2 and 71 nM respectively). Displays no activity at calcitonin-gene related peptide (CGRP) and adrenomedullin receptors. Inhibits formation of multinuclear...
| CAS | 697327-12-1 |
| MW: | 4098.88 D |
484.00€
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CTAP
Item number: TGM-TP2050-1mg
Description: Potent and selective µ opioid receptor antagonist (IC50 = 3.5 nM). Displays > 1200-fold selectivity over delta opioid and somatostatin receptors. Brain penetrant and active in vivo. Smiles:...
| CAS | 103429-32-9 |
| MW: | 1104.32 D |
740.00€
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alpha-Conotoxin PIA acetate
Item number: TGM-TP2065L-100mg
Description: alpha-Conotoxin PIA acetate is an antagonist of nicotinic acetylcholine receptor (nAChR) mainly targeting alpha6 and alpha3 subunits. Target: AChR. References: Seung-Wook Chi, et al. Solution Structure of Alpha-Conotoxin PIA, a Novel Antagonist of alpha6 Subunit Containing Nicotinic Acetylcholine...
From 91.00€
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