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Saralasin
Item number: TGM-TP1929-5mg
Description: Competitive non-selective angiotensin II antagonist. References: Steinhausen et al (1986) Angiotensin II control of the renal microcirculation: effect of blockade by saralasin. Kidney Int. 30 56 PMID:
| CAS | 34273-10-4 |
| MW: | 912 D |
96.00€
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[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P
Item number: TGM-TP1931-1mg
Description: Broad spectrum neuropeptide inverse agonist and antagonist. Potent full inverse agonist for the ghrelin receptor (EC50 = 5.2 nM), diminishes constitutive ghrelin receptor signaling. Also antagonist at tachykinin, bradykinin, CCK and bombesin receptors. Induces apoptosis and inhibits cancer cell growth...
| CAS | 96736-12-8 |
| MW: | 1516.85 D |
135.00€
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pep2-AVKI
Item number: TGM-TP1942-2mg
Description: pep2-AVKI is an inhibitor peptide that selectively disrupts binding of the AMPA receptor subunit GluA2 (at the C-terminal PDZ site) to protein interacting with C kinase (PICK1). Does not affect binding of GluA2 to GRIP or ABP and does not increase AMPA current amplitude or affect long term depression...
| CAS | 1315378-69-8 |
| MW: | 1268.47 D |
261.00€
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pep2-EVKI
Item number: TGM-TP1943-2mg
Description: pep2-EVKI is an inhibitor peptide that selectively disrupts binding of the AMPA receptor subunit GluA2 (at the C-terminal PDZ site) to protein interacting with C kinase (PICK1). Does not affect binding of GluA2 to GRIP or ABP and does not increase AMPA current amplitude or affect long term depression...
| CAS | 1315378-67-6 |
| MW: | 1326.51 D |
225.00€
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pep2-SVKI
Item number: TGM-TP1944-2mg
Description: Inhibitor peptide corresponding to last 10 amino acids of the C-terminus of the GluA2 AMPA receptor subunit. Disrupts binding of GluA2 (at the C-terminal PDZ site) with glutamate receptor interacting protein (GRIP), AMPA receptor binding protein (ABP) and protein interacting with C kinase (PICK1)....
| CAS | 328944-75-8 |
| MW: | 1284.47 D |
156.00€
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QWF
Item number: TGM-TP1946-5mg
Description: Tripeptide substance P (SP) antagonist (IC50 = 90 µM). Also inhibits binding of SP to Mas-related GPCR (MRGPR) X2. Inhibits SP-induced IgE-independent degranulation of mast cells in vitro. Inhibits compound 48/80-induced MRGPRX2 activation and scratching in mice in vivo. References: Hagiwara et al...
| CAS | 126088-82-2 |
| MW: | 697.78 D |
723.00€
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P110
Item number: TGM-TP1947-100mg
Description: Dynamin-related protein 1 (Drp1) inhibitor, inhibits Drp1 GTPase activity. Displays no effect on dynamin 1 or other mitochondrial dynamics-related proteins. Inhibits mitochondrial fission, dysfunction and reactive oxygen species (ROS) production in vitro. Reduces programmed cell death and improves cell...
| MW: | 2411.8 D |
From 34.00€
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PKC zeta pseudosubstrate
Item number: TGM-TP1956-1mg
Description: Inhibitor of protein kinase C (PKC) zeta, attached to cell permeabilisation Antennapedia domain vector peptide. Consists of amino acids 113 - 129 of PKC zeta pseudosubstrate domain linked by a disulphide bridge to the Antennapedia domain vector peptide. The Antennapedia peptide is actively taken up by...
| MW: | 4673.59 D |
331.00€
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PM 102
Item number: TGM-TP1959-1mg
Description: Peptide that reverses the anticoagulant effect of heparin. Potently binds heparin (Kd = 36 nM in vitro). References: Cushing et al (2010) Reversal of heparin-induced increases in aPTT in the rat by PM102, a novel he. antagonist. Eur.J.Pharmacol. 635 165 PMID:
| CAS | 1234564-95-4 |
| MW: | 5830 D |
298.00€
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PR 39 (porcine) acetate
Item number: TGM-TP1961L-10mg
Description: PR 39 (porcine) acetate is a noncompetitive, reversible and allosteric proteasome inhibitor. PR 39 (porcine) acetate reversibly binds to the alpha7 subunit of the proteasome and blocks degradation of NF-kappaB inhibitor IkappaBalpha by the ubiquitin-proteasome pathway. Target: Proteasome,...
From 186.00€
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Pam2CSK4
Item number: TGM-TP1962-1mg
Description: Toll-like receptor 2/6 (TLR2/6) agonist. Induces TNF-alpha production in human mononuclear cells. Also induces proliferation and activation of mouse splenic B cells. References: Boeglin et al (2011) Toll-like receptor agonists synergize with CD40L to induce either proliferation or plasma cell...
| CAS | 868247-72-7 |
| MW: | 1271.83 D |
815.00€
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ProTx III
Item number: TGM-TP1969-10mg
Description: Potent Nav1.7 blocker (IC50 = 2.5 nM). Also inhibits Nav1.1, Nav1.2, Nav1.3 and Nav1.6 in the nanomolar range. Exhibits no effects on Cav channels or nAChR at 5 µM. Demonstrates analgesic activity in vivo, antagonizes effects of scorpion-venom toxin OD1 at Nav1.7. References: Cardoso et al (2015)...
| MW: | 3802.41 D |
1,986.00€
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