Tumor Necrosis Factor Receptor Superfamily Member 17, active (TNFRSF17), Recombinant, Human

Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK. Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by its ability to inhibit APRIL-mediated proliferation of anti-IgM stimulated murine B cells is no less than 40ng/ml, corresponding to a specific activity of ? 2.5x10e4 IU/mg in the presence of 100ng/ml human APRIL. Sequence: AGQCSQNEYF DSLLHACIPC QLRCSSNTPP LTCQRYCNAS VTNSVKGTNA, Molecular Weight: 5.4kD, PubMed ID: 1396583, 8165126, 11528522, 17825416, 10493829, 15616553, 10903733, 10801128, 10973284, 10908663, 12721620, 15542592, Gene Name: TNFRSF17,BCM,BCMA, Swiss Prot: Q02223, Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.