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Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo. (www.uniprot.org) Produced in E.coli. Single, non-glycosylated, polypeptide chain containing 171 amino acids. The ED50 as determined by the cytolysis of murine L929 cells in the presence of Actinomycin D is < 0.05ng/ml.
Keywords: | Lymphotoxin-alpha, LT-alpha, TNF-beta, Tumor necrosis factor ligand superfamily member 1, LTA, LT, TNFB, TNFSF1 |
Supplier: | Biomol GmbH |
Supplier-Nr: | 50439.1 |
Properties
Application: | Cell culture |
Conjugate: | No |
Expressed in: | E.coli |
Origin: | Human |
MW: | 18650 D |
Purity: | >98% |
Database Information
KEGG ID : | K05468 | Find alternatives |
UniProt ID : | P01374 | Find alternatives |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: +20°C) |