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Tumor Necrosis Factor alpha, rat recombinant (rrTNF-a)
Product information "Tumor Necrosis Factor alpha, rat recombinant (rrTNF-a)"
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. (www.uniprot.org) Produced in E.coli. Single, non-glycosylated polypeptide chain containing 157 amino acids. The ED50 as determined by the cytolysis of murine L929 cells in the presence of Actinomycin D is < 0.05ng/ml.