Trefoil Factor-3, human recombinant (rHuTFF3 )

TFF-3 Human recombinant produced in E.coli is a homodimeric, non-glycosylated, polypeptide chain containing 2 x 59 amino acid chains which includes a 40 amino acid trefoIL-motif containing 3 conserved interamolecular disulfide bonds and having a total molecular mass of 13.2kDa. Proteins of the TFF family are characterized by obtaining a minimum of 1 copy of the trefoIL-motif, a 40-amino acid domain that contains 3 conserved disulfides. TrefoIL-Factors are stable secretory proteins expressed in gastrointestinal mucosa which protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium.TFF2 inhibits gastric acid motility and secretion. TFF2 stabilizes glycoproteins in the mucus gel through interactions with carbohydrate side chains. TFF3 induces ciliogenesis and promotes airway epithelial ciliated cell differentiation, relatively through an epidermal growth factor receptor-dependent pathway. TFF3 overexpression is crucial for progression in mouse and human hepatocellular carcinogenesis. TFF-3 is normally expressed in hepatocellular carcinoma and its expression associates with tumor grade.