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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
E-PKSH033140.10 | 10 µg | - |
7 - 16 business days* |
212.00€
|
|||
E-PKSH033140.50 | 50 µg | - |
7 - 16 business days* |
622.00€
|
Activity: Measured by its ability to inhibit the IL-4-dependent proliferation of TF-1 mouse T... more
Product information "Transforming Growth Factor ß-3/TGFB3 Protein (recombinant human)"
Activity: Measured by its ability to inhibit the IL-4-dependent proliferation of TF-1 mouse T cells. The ED50 for this effect is less than 2 ng/ml. Protein Construction: Recombinant Human/Mouse Transforming Growth Factor beta 3 is produced by our Mammalian expressionsystem and the target gene encoding Ala301-Ser412(Tyr340Phe) is expressed. Sequence: Ala301-Ser412(Tyr340Phe). Endotoxin: < 1.0 EU per µg as determined by the LAL method. Apparent Molecular Mass: 14 kDa. Protein function: Transforming growth factor beta 3(TGFB3) is a member of a TGF -ß superfamily which is defined by theirstructural and functional similarities. TGFB3 is secreted as a complex with LAP. This latent form of TGFB3 becomes active upon cleavage by plasmin, matrix metalloproteases, thrombospondin -1, and a subset ofintegrins. It binds with high affinity to TGF- ß RII, a type II serine/threonine kinase receptor. TGFB3 is involved incell differentiation, embryogenesis and development.It is believed to regulate molecules involved in cellularadhesion and extracellular matrix (ECM) formation during the process of palate development. Without TGF-ß3, mammals develop a deformity known as a cleft palate. Protein function: Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively. [The UniProt Consortium]
Keywords: | TGFB3, Recombinant Human Transforming Growth Factor ß-3/TGFB3 Protein |
Supplier: | Elabscience |
Supplier-Nr: | E-PKSH033140 |
Properties
Conjugate: | No |
Host: | Human cells |
Species reactivity: | human |
MW: | 12.7 kD |
Format: | Lyophilized |
Database Information
KEGG ID : | K13377 | Matching products |
UniProt ID : | P10600 | Matching products |
Gene ID | GeneID 7043 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | +4°C (International: +20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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