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Product information "TNF alpha (TNFSF2), rabbit recombinant (rraTNFalpha)"
Produced in Yeast. Amino acid sequence: SASRALSDKP LAHVVANPQV EGQLQWLSQR ANALLANGMK LTDNQLVVPA DGLYLIYSQV LFSGQGCRSY VLLTHTVSRF AVSYPNKVNL LSAIKSPCHR ETPEEAEPMA WYEPIYLGGV FQLEKGDRLS TEVNQPEYLD LAESGQVYFG IIAL (154). Protein function: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. [The UniProt Consortium]