Proepiregulin, cleaved to Epiregulin, active (EREG), Recombinant, Human

Ligand of the EGF receptor/EGFR and ERBB4. May be a mediator of localized cell proliferation. As a mitogen it may stimulate cell proliferation and/or angiogenesis. {ECO:0000269, PubMed:9419975}. Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine Balb/c 3T3 cells is less than 2ng/ml, corresponding to a specific activity of ? 5.0x10e5 IU/mg. Sequence: VAQVSITKCS SDMNGYCLHG QCIYLVDMSQ NYCRCEVGYT GVRCEHFFL, Molecular Weight: 5.6kD, PubMed ID: 9337852, 14702039, 15489334, 9419975, 14572630, 16959974, Gene Name: EREG, Swiss Prot: O14944, Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.