PDGF-AA (human), animal-free recombinant

PDGF-AA (human), animal-free recombinant
Item number Size Datasheet Manual SDS Delivery time Quantity Price
PC-AF-H-PDGF-AA-2UG 2 µg - - -

10 - 14 business days*

112.00€
PC-AF-H-PDGF-AA-5UG 5 µg - - -

10 - 14 business days*

167.00€
PC-AF-H-PDGF-AA-10UG 10 µg - - -

10 - 14 business days*

222.00€
PC-AF-H-PDGF-AA-25UG 25 µg - - -

10 - 14 business days*

418.00€
PC-AF-H-PDGF-AA-50UG 50 µg - - -

10 - 14 business days*

676.00€
 
Product Description: PDGFs exist as disulfide-linked dimers comprising two polypeptide chains,... more
Product information "PDGF-AA (human), animal-free recombinant"
Product Description: PDGFs exist as disulfide-linked dimers comprising two polypeptide chains, PDGF-A and PDGF-B, each weighing between 12.0 and 13.5 kDa. Among the three naturally occurring PDGFs-PDGF-AA, PDGF-BB, and PDGF-AB-all are potent mitogens affecting various cell types, including smooth muscle cells, connective tissue cells, bone and cartilage cells, and certain blood cells. These growth factors are stored in platelet alpha-granules and released upon platelet activation, contributing to processes like hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. PDGFs engage two distinct signaling receptors known as PDGFR-alpha and PDGFR-beta. PDGFR-alpha serves as a high-affinity receptor for all three PDGF forms, while PDGFR-beta selectively interacts with PDGF-BB and PDGF-AB. Recombinant Human PDGF-AA is a 28.5 kDa disulfide-linked homodimer consisting of two A chains, totaling 250 amino acids.. Amino acid sequence: SIEEAVPAVC KTRTVIYEIP RSQVDPTSAN FLIWPPCVEV KRCTGCCNTS SVKCQPSRVH HRSVKVAKVE YVRKKPKLKE VQVRLEEHLE CACATTSLNP DYREEDTGRP RESGKKRKRK RLKPT. Endotoxin concentration: <0.1 EU/µg. Activity: Determined by the dose-dependent stimulation of the proliferation of Balb/c 3T3 cells. The expected ED50 for this effect is 1.0-3.0 ng/ml. Contains no preservative. Protein function: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB. [The UniProt Consortium]
Keywords: PDGF1, PDGFA, PDGF-1, PDGF subunit A, Platelet-derived growth factor A chain, Platelet-derived growth factor subunit A, Platelet-derived growth factor alpha polypeptide, Animal-Free Recombinant Human PDGF-AA (25 ug)
Supplier: Pacific Coast Bio
Supplier-Nr: AF-H-PDGF-AA

Properties

Conjugate: No
Host: E.coli
Species reactivity: human (Expected: human, monkey, mouse, rat)
MW: 28.5 kD
Purity: >98% (SDS & HPLC)
Format: Lyophilized

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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