OX40 Ligand/TNFSF4/OX40L Protein(N-8His) (recombinant mouse)

Protein Construction: Recombinant Mouse OX40 Ligand is produced by our Mammalian expression system and the target gene encoding Ser51-Leu198 is expressed with a 8His tag at the N-terminus. Sequence: Ser51-Leu198. Fusion tag: N-8His Endotoxin: < 1.0 EU per µg as determined by the LAL method. Apparent Molecular Mass: 20-23 kDa. Protein function: OX40 ligand (OX40L), also called CD252, is a single-pass type II membrane protein of the TNF/TNF receptor superfamily. OX40L is expressed by DCs, macrophages and B cells and signals via its cognate receptor OX40 which is mainly expressed on APCs. OX40L/OX40 interactions are important in T-cell activation and survival and for the generation of memory T cells from activated effector T cells. OX40L-OX40 co-stimulation leads to activation of TNF receptor associated factor (TRAF) 2, 3 and 5. This pathway has been shown to prolong the survival of effector CD4+Th cells as well as contributes to generation of memory T cells. Protein function: Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production. [The UniProt Consortium]