NT-3 (human), animal-free recombinant

Product Description: NT-3, a neurotrophic factor, shares structural kinship with beta-NGF, BDNF, and NT-4, all part of the cysteine-knot family of growth factors known for their stable dimeric structures. It's predominantly expressed by neurons in the central nervous system and activates signaling pathways through the trk receptors. NT-3 plays a vital role in promoting the growth and survival of both nerve cells and glial cells. Notably, the amino acid sequences of Human, murine, and rat NT-3 are identical. Recombinant Human NT-3 forms a noncovalently linked homodimer consisting of two 13.6 kDa polypeptide monomers, totaling 240 amino acid residues. . Amino acid sequence: MYAEHKSHRG EYSVCDSESL WVTDKSSAID IRGHQVTVLG EIKTGNSPVK QYFYETRCKE ARPVKNGCRG IDDKHWNSQC KTSQTYVRAL TSENNKLVGW RWIRIDTSCV CALSRKIGRT. Endotoxin concentration: <0.1 EU/µg. Activity: Determined by its ability to bind recombinant human TrkB Fc Chimera in a functional ELISA. Contains no preservative. Protein function: Seems to promote the survival of visceral and proprioceptive sensory neurons. [The UniProt Consortium]