Neuregulin-4 (NRG4) Recombinant (Human)

Recombinant human neuregulin-4 (NRG4), partial length, encompassing amino acids 2-62, with N-terminal Gly-Pro fused. The construct is tag-free and was affinity purified. Neuregulins (NDF, heregulin, GGF ARIA, or SMDF) are EGF- like growth and differentiation factors that signal through tyrosine kinase receptors of the ErbB family. The ErbB2 and ErbB4 receptors cooperate in transmission of neuregulin-1 signals in the heart, whereas ErbB2 and ErbB3 cooperate in neural crest cells.