Neuregulin 1 beta (NRG1-beta) Recombinant (Human)

Recombinant human neurgulin 1 beta (NRG1-beta), partial length, encompassing amino acids 2-246. This construct is tag-free and was affinity purified. Neuroregulins (NRG) are polypeptide growth factors, that bind to HER proteins, with NRG1 being the most studied of the four known proteins in this family. NRG1 specifically binds to HER3 and HER4. NRG1 binding induces dimerization of HER3 with HER2, transphosphorylation, and activation of several pathways such as the PI3K(phosphoinositide 3-kinase)/AKT signaling pathway. Due to HER3 cell surface expression in a variety of cancers and correlation with decreased survival, HER3 is a prospective therapeutic target for antibody-drug conjugate (ADC) development. It has been suggested that elevated levels of NRG1 in the TME (tumor microenvironment) canbe considered as a predictive biomarker for the effectiveness of anti-HER3 antibody treatments in cancer. Binding of NRG1 to HER4 play an important role in cortical development, and cardiomyocyte proliferation and regeneration, by inducing dimerization to HER2 and activation of multiple signaling pathways.