Mouse IL-1b, recombinant

Recombinant Mouse Interleukin-1 Beta is produced by our E.coli expression system and the target gene encoding Val118-Ser269 is expressed. Protein function: Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells. Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6. [The UniProt Consortium]