Interleukin-36 gamma/IL-36 gamma/IL-1F9 (recombinant mouse)

Protein Construction: Recombinant Mouse Interleukin-36 Gamma is produced by our E.coli expression system and the target gene encoding Gly13-Ser164 is expressed. Sequence: Gly13-Ser164. Endotoxin: < 1.0 EU per µg as determined by the LAL method. Apparent Molecular Mass: 17 kDa. Protein function: Interleukin-36 gamma (IL-36gamma) is a member of the interleukin 1 cytokine family that includes three closely related genes, IL-36alpha, beta, and gamma, formerly known as IL-1F6, F8, and F9 respectively. IL-36alpha has been detected in both neuronal and synovial tissue, whereas IL-36beta and IL-36gamma are expressed in both cutaneous and mucosal epithelial cells, including the respiratory tract. IL-36beta and IL-36gamma stimulate proliferation, maturation and/or cytokine expression by innate immune cells (such as keratinocytes and dendritic cells), and adaptive immune cells (neutrophils and T-cells) in both humans and mice. The activity of IL-36alpha is mediated by interleukin 1 receptor-like 2 (IL1RL2/IL1R-rp2), and is specifically inhibited by interleukin 1 family, member 5 (IL1F5/IL-1 delta). IL-36gamma plays an important role in communicating the cell death to surrounding cells. Protein function: Functions as an agonist of NF-kappa B activation through the orphan IL-1-receptor-related protein 2/IL1RL2. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response, similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. May play a role in proinflammatory responses during particular neutrophilic airway inflammation. May be involved in the innate immune response to fungal pathogens. Induces the production of proinflammatory cytokines in bone marrow-derived dendritic cells (BMDCs), including IL-12, Il-1 beta, IL- 6, TNF-alpha and IL-23. Involved in dendritic cell maturation by stimulating the surface expression of CD80, CD86 and MHC class II. Induces the production of IFN-gamma, IL-4 and IL-17 by cultured CD4(+) T-cells and splenocytes. [The UniProt Consortium]