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Mouse recombinant IL31 produced in E.coli is a single, non-glycosylated, polypeptide chain containing 141 amino acids and having a molecular mass of 15.7 kDa. IL-31 produced by activated Th2-type T cells, cooperates with a heterodimeric receptor consisting of IL-31 Receptor Anatagonist and Onconstatin-M Receptor that is continuesly expressed on epithelial cells and keratinocytes. IL-31 plays a role in the promotion of allergic skin disorders and in regulating other allergic diseases, such as asthma. IL-31 is involved in the itching sensation and endorses the scratching behavior in NC/Nga mice with atopic dermatitis. IL-31 expression is connectd with CLA(+) T cells and contributes to the development of atopic dermatitis-induced skin inflammation and pruritus. IL-31 is a powerful inducer of proinflammatory mediators in human colonic SEMFs. IL-31 takes part as a proinflammatory cytokine derived from Th2 cells.
Keywords: | Interleukin 31, IL31, IL-31. |
Supplier: | Biomol GmbH |
Supplier-Nr: | 97509 |
Properties
Application: | Bioassay |
Conjugate: | No |
Expressed in: | E.coli |
Origin: | Mouse |
MW: | 15700 D |
Purity: | >97% |
Format: | Lyophilized |
Database Information
KEGG ID : | K22631 | Find alternatives |
UniProt ID : | Q6EAL8 | Find alternatives |
Gene ID | GeneID 76399 | Find alternatives |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: +20°C) |
Our products are for laboratory research use only: Not for administration to humans!