Interferon Lambda-2/IL-28A Protein(C-6His) (recombinant human)

Interferon Lambda-2/IL-28A Protein(C-6His) (recombinant human)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
E-PKSH032602.10 10 µg -

7 - 16 business days*

152.00€
E-PKSH032602.50 50 µg -

7 - 16 business days*

446.00€
 
Protein Construction: Recombinant Human Interferon Lambda-2 is produced by our Mammalian... more
Product information "Interferon Lambda-2/IL-28A Protein(C-6His) (recombinant human)"
Protein Construction: Recombinant Human Interferon Lambda-2 is produced by our Mammalian expression system and the target gene encoding Val26-Val200 is expressed with a 6His tag at the C-terminus. Sequence: Val26-Val200. Fusion tag: C-6His Endotoxin: < 1.0 EU per µg as determined by the LAL method. Apparent Molecular Mass: 20 kDa. Protein function: IL-28A (Interferon-?2? IFN-?2), IL-28B/IFN-?3, and IL-29/IFN-?1 are type III interferons which are distantly related to IL-10 family and type I IFN family cytokines. Mature human IL-28A is an approximately 22-25 kDa protein that shares 66% amino acid (aa) sequence identity with mouse and rat IL-28A and shows cross-species activity. It shares 96% and 70% aa sequence identity with human IL-28B and IL-29, respectively. IL-28A promotes the Th1 polarization of dendritic cells in the airway and inhibits Th2 and Th17 mediated inflammation. IL-28A additionally exhibits anti-tumor activity, in part by enhancing IL-12 dependent anti-tumor CTL responses in vivo. In contrast, it is up-regulated in invasive bladder cancer where it promotes tumor cell migration. Protein function: Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN- stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type- selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression. [The UniProt Consortium]
Keywords: IL28A, IFNL2, IL-28A, IFN-lambda-2, Interleukin-28A, Cytokine Zcyto20, Interferon lambda-2, Recombinant Human Interferon Lambda-2/IL-28A Protein(C-6His)
Supplier: Elabscience
Supplier-Nr: E-PKSH032602

Properties

Conjugate: No
Host: Human cells
Species reactivity: human
MW: 20.6 kD
Format: Lyophilized

Handling & Safety

Storage: -80°C
Shipping: +4°C (International: +20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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