Insulin-Like Growth Factor-I, human recombinant (rHuIGF-1)

The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. (www.uniprot.org) Produced in E.coli. Single, non-glycosylated, polypeptide chain containing 70 amino acids. The ED50, calculated by the dose-dependant proliferation of murine BALB\C 3T3 cells (measured by H-thymidine uptake) is < 1.0 ng/ml.