IL-6 (Interleukin 6) Recombinant (Human)

Recombinant human Interleukin 6 (IL-6), full length, encompassing amino acids 30-212, corresponding to the mature protein. This construct is tag-free. This protein was affinity purified. IL-6 (interleukin-6), instantly produced at the site of inflammation, plays a critical role in host defense through the stimulation of acute phase responses, hematopoiesis, and immune reactions. IL-6 exerts stimulatory effects on T- and B-cells, by acting on the STAT3 (signal transducer and activator of transcription 3) signaling pathway. Dysregulated IL-6 expression shows a pathological effect on chronic inflammation, autoimmunity and cancer. Il-6 expression is regulated at multiple levels, with transcription being induced by several types of stimuli, such as TLR (Toll-like receptor) ligands, TNFalpha (tumor necrosis factor alpha) and ROS (reactive oxygen species). IL-6 is also involved in cell senescence and can trigger senescence-induced inflammation and agerelated diseases. The use of the anti-IL-6R antibody tocilizumab has resulted in positive outcomes in the treatment of RA (rheumatoid arthritis) and Castleman's disease. Hence, the development of molecules able to target the IL-6 and IL-6 signaling pathway is an active area of research and can be an effective strategy for prevention and treatment of chronic inflammatory diseases and cancer.