IL-6, bovine recombinant (rboIL-6)

Biologically active. Produced in Yeast. Amino acid sequence: GPLGEDFKND TTPGRLLLTT PEKTEALIKR MVDKISAMRK EICEKNDECE SSKETLAENK LNLPKMEEKD GCFQSGFNQA ICLIRTTAGL LEYQIYLDYL QNEYEGNQEN VRDLRKNIRT LIQILKQKIA DLITTPATNT DLLEKMQSSN EWVKNAKIIL ILRNLENFLQ FSLRAIRMK. Protein function: Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig- secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation. [The UniProt Consortium]