IL-5 (human), animal-free recombinant

Product Description: IL-5 functions as a growth factor in hematopoiesis, fostering the proliferation and activation of eosinophils. Its production primarily stems from mast cells, T cells, and eosinophils themselves. IL-5 plays a pivotal role in bolstering cell-mediated immunity against parasitic infections and specific tumors. Elevated IL-5 levels correlate with eosinophilia, a condition associated with the onset of asthma and other allergic disorders. Notably, both human and murine IL-5 exhibit cross-species reactivity. Recombinant Human IL-5 constitutes a 26.5 kDa disulfide-linked homodimeric protein, comprised of two 116 amino acid chains.. Amino acid sequence: MIPTEIPTSA LVKETLALLS THRTLLIANE TLRIPVPVHK NHQLCTEEIF QGIGTLESQT VQGGTVERLF KNLSLIKKYI DGQKKKCGEE RRRVNQFLDY LQEFLGVMNT EWIIES. Endotoxin concentration: <0.1 EU/µg. Activity: The ED50 as determined by the dose-dependent proliferation of TF-1 cells was = 0.15 ng/ml, corresponding to a specific activity of > 6.6 x 10^6 units/mg. Contains no preservative. Protein function: Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. [The UniProt Consortium]