IL-3 (human), animal-free recombinant

Product Description: IL-3 acts as a crucial hematopoietic growth factor, supporting the survival, differentiation, and proliferation of specialized progenitor cells spanning various lineages such as megakaryocytes, granulocyte-macrophages, erythrocytes, eosinophils, basophils, and mast cells. It is produced by T cells, mast cells, and eosinophils, contributing significantly to processes like thrombopoiesis, phagocytosis, and antibody-mediated cellular cytotoxicity. IL-3 also triggers monocyte activation, suggesting potential additional roles in immunoregulation. Many of its effects hinge on co-stimulation with other cytokines. Notably, IL-3 shows species-specific variability in glycosylation patterns. The recombinant Human IL-3 is a 15.0 kDa globular protein comprising 133 amino acid residues. . Amino acid sequence: APMTQTTSLK TSWVNCSNMI DEIITHLKQP PLPLLDFNNL NGEDQDILME NNLRRPNLEA FNRAVKSLQN ASAIESILKN LLPCLPLATA APTRHPIHIK DGDWNEFRRK LTFYLKTLEN AQAQQTTLSL AIF. Endotoxin concentration: <0.1 EU/µg. Activity: The ED50 was determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is = 0.1 ng/ml, corresponding to a specific activity of > 1 x 10^7 units/mg. Contains no preservative. Protein function: Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. [The UniProt Consortium]