IL-1beta, Mouse(CHO-expressed)

Interleukin-1 (IL-1) is a family of cytokines that play a central role in the regulation of immune and inflammatory responses to infections or sterile insults. IL-1alpha and IL-1beta are the first two members discovered in this family, which are the products of distinct genes recognizing the same cell surface receptors. IL-1alpha and IL-1beta are structurally related polypeptides that show approximately 25% homology at the amino acid level. Both proteins are produced by a wide variety of cells in response to stimuli such as those produced by inflammatory agents, infections, or microbial endotoxins. The proteins are synthesized as 31 kDa precursors that are subsequently cleaved into proteins with molecular weights of approximately 17.5 kDa. The specific protease responsible for the processing of IL-1beta is interleukin 1beta-converting enzyme (ICE)/caspase-1. Mature human and mouse IL-1beta share approximately 75% amino acid sequence identity where human IL-1beta has been found to be active on murine cell lines.