IL-11 (human), animal-free recombinant

Product Description: IL-11, a versatile cytokine, is synthesized by stromal cells like fibroblasts, epithelial cells, and osteoclasts. Its expression spans various tissues such as the thymus, lung, bone, connective tissue, and central nervous system. IL-11 holds a crucial regulatory role in hematopoiesis by stimulating the growth of myeloid, erythroid, and megakaryocyte progenitor cells. Additionally, it influences bone metabolism, suppresses the production of proinflammatory cytokines, and provides protection against gastromucosal injury. Recombinant Human IL-11 is a 19.3 kDa protein comprising 179 amino acid residues. . Amino acid sequence: MPGPPPGPPR VSPDPRAELD STVLLTRSLL ADTRQLAAQL RDKFPADGDH NLDSLPTLAM SAGALGALQL PGVLTRLRAD LLSYLRHVQW LRRAGGSSLK TLEPELGTLQ ARLDRLLRRL QLLMSRLALP QPPPDPPAPP LAPPSSAWGG IRAAHAILGG LHLTLDWAVR GLLLLKTRL. Endotoxin concentration: <0.1 EU/µg. Activity: The ED50 was determined by the dose-dependent stimulation of the proliferation of murine T11 cells is = 2.0 ng/ml, corresponding to a specific activity of > 5 x 10^5 units/mg. Contains no preservative. Protein function: Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed:2145578). Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and IL11RA activates a signaling cascade that promotes cell proliferation (PubMed:12919066). Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. The interaction with the membrane-bound IL11RA and IL6ST stimulates 'classic signaling', whereas the binding of IL11 and soluble IL11RA to IL6ST stimulates 'trans-signaling' (PubMed:30279168). [The UniProt Consortium]