IFN-gamma, Mouse

Sharing 41% sequence identity with human Interferon gamma (hIFN--gamma), mouse IFN gamma (mIFN--gamma)is a macrophage-activating factor.The active form of IFN--gamma is an antiparallel dimer that sets off IFN--gamma/JAK/STAT pathway. IFN--gamma signaling does diverse biological functions primarily related to host defense and immune regulation, including antiviral and antibacterial defense, apoptosis, inflammation, and innate and acquired immunity.While IFN--gamma-induced inflammatory cascade summons a variety of immune-related cell types, such as macrophages, natural killer (NK) cells and cytotoxic T lymphocytes (CTLs), IFN--gamma is also implicated in resistance to NK cell and CTL responses and in immune escape in avariety of cancers.