Human Osteocrin, recombinant (N-6His)

Recombinant Human Osteocrin is produced by our E.coli expression system and the target gene encoding Val28-Gly133 is expressed with a 6His tag at the N-terminus. Protein function: Hormone that acts as a regulator of dendritic growth in the developing cerebral cortex in response to sensory experience (PubMed:27830782). Induced in the brain following membrane depolarization and inhibits dendritic branching in neurons of the developing cortex (PubMed:27830782). Probably acts by binding to natriuretic peptide receptor NPR3/NPR-C, thereby preventing binding between NPR3/NPR-C and natriuretic peptides, leading to increase cGMP production. [The UniProt Consortium]