Human Latent Activin A Protein

Recombinant Human Latent Activin A Protein is expressed from HEK293 with His tag at the N-terminus.It contains Ser21-Ser426. Activin-A, a member of the TGF-beta superfamily, Extensive research over the past decades illuminated fundamental roles for activin-A in essential biologic processes, including embryonic development, stem cell maintenance and differentiation, haematopoiesis, cell proliferation and tissue fibrosis. Activin-A signals through two type I and two type II receptors which, upon ligand binding, activate their kinase activity, phosphorylate the SMAD2 and 3 intracellular signaling mediators that form a complex with SMAD4, translocate to the nucleus and activate or silence gene expression.