Human IL-2, recombinant

IL-2, also known as T cell growth factor (TCGF), is the most important cytokine that causes T cell proliferation. IL-2 specifically binds to the IL-2 receptor (IL-2R) on the surface of T cells to activate T cells, for proliferation. Besides, IL-2 stimulates the growth of NK cells and enhances lethality of NK cells. IL-2, together with other T cell growth factors from the family activates and duplicates CD4+ and CD8+T cells by the common receptors. IL-2 activates T cells and NK cells by autocrine and paracrine modes. Unlike T cells, NK cells do not express alpha receptor subunit and therefore have a low affinity for IL-2. However, IL-2 can promote NK cell proliferation, enhance cell activity and generating other cytokines. B cells are also activated by IL-2, which leads to proliferation and cell differentiation. Recombinant Human IL-2 is produced by E.coli expression system, and is produced with raw materials of pharmaceutical applicable level. The host protein residue, nucleic acid residue and common pathogens are strictly controlled, and the production and quality management procedures of the product comply with GMP regulations to ensure the traceability of the production process and all raw materials.