Human IL-15RA&IL-15, recombinant (C-Fc)

Recombinant Human Interleukin-15 Receptor Alpha & Interleukin-15 Fusion Protein is produced by our Mammalian expression system and the target gene encoding Ile31-Asp96&Asn49-Ser162(Asn120Asp) is expressed with a human IgG1 Fc tag at the C-terminus. Protein function: High-affinity receptor for interleukin-15 (PubMed:8530383). Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. In neutrophils, binds and activates kinase SYK in response to IL15 stimulation (PubMed:15123770). In neutrophils, required for IL15- induced phagocytosis in a SYK-dependent manner (PubMed:15123770). Expression of different isoforms may alter or interfere with signal transduction (PubMed:10480910). [The UniProt Consortium]