Growth arrest-specific protein 6 (Gas6), mouse, recombinant

Organism: Mus musculus (Mouse). Source: Mammalian cell. Expression Region: 28-674aa. Protein Length: Full Length of Mature Protein. Tag Info: C-terminal 10xHis-tagged. Target Protein Sequence: VLLRAREAAQ FLRPRQRRAY QVFEEAKQGH LERECVEEVC SKEEAREVFE NDPETEYFYP RYQECMRKYG RPEEKNPDFA KCVQNLPDQC TPNPCDKKGT HICQDLMGNF FCVCTDGWGG RLCDKDVNEC VQKNGGCSQV CHNKPGSFQC ACHSGFSLAS DGQTCQDIDE CTDSDTCGDA RCKNLPGSYS CLCDEGYTYS SKEKTCQDVD ECQQDRCEQT CVNSPGSYTC HCDGRGGLKL SPDMDTCEDI LPCVPFSMAK SVKSLYLGRM FSGTPVIRLR FKRLQPTRLL AEFDFRTFDP EGVLFFAGGR SDSTWIVLGL RAGRLELQLR YNGVGRITSS GPTINHGMWQ TISVEELERN LVIKVNKDAV MKIAVAGELF QLERGLYHLN LTVGGIPFKE SELVQPINPR LDGCMRSWNW LNGEDSAIQE TVKANTKMQC FSVTERGSFF PGNGFATYRL NYTRTSLDVG TETTWEVKVV ARIRPATDTG VLLALVGDDD VVPISVALVD YHSTKKLKKQ LVVLAVEDVA LALMEIKVCD SQEHTVTVSL REGEATLEVD GTKGQSEVST AQLQERLDTL KTHLQGSVHT YVGGLPEVSV ISAPVTAFYR GCMTLEVNGK ILDLDTASYK HSDITSHSCP PVEHATP. Purity: Greater than 95% as determined by SDS-PAGE. Endotoxin: n/a. Biological Activity: n/a. Form: Liquid or Lyophilized powder. Buffer: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0. Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20 °C/-80 °C. Our default final concentration of glycerol is 50%. Customers could use it as reference. Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 °C/-80 °C. The shelf life of lyophilized form is 12 months at -20 °C/-80 °C. Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 °C for up to one week. Relevance: Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Reference: n/a. Function: nan