Glia Maturation Factor beta (GMFb) Recombinant (Human)

Recombinant human glia maturation factor beta (GMFb), full length encompassing amino acids 1-142. This construct is tag-free and was affinity purified. GMF-beta is a 17- kDa brain-specific protein that was isolated from bovine brain homogenate as a substance inducing the maturation of normal neurons as well as glial cells, and at first, it was considered to be a neurotrophic factor. The amino acid sequence of GMFB is highly conserved among many species, suggesting that it plays basic roles across many species. The expression of GMF-b is largely limited to the brain, especially the glial cells and some neurons . Schwann cells of the distal segment of the transected nerve express GMF-b, and this induction of GMF-b coincides with the temporal expression of nerve growth factor receptors in the cell. This protein causes differentiation of brain cells, stimulation of neural regeneration, and inhibition of proliferation of tumor cells.