G-CSF (human), animal-free recombinant

Product Description: G-CSF serves as a hematopoietic growth factor, prompting the growth of dedicated progenitor cells into neutrophils and boosting the capabilities of mature end-cells. Its production is triggered by specific signals from various cells like macrophages, fibroblasts, endothelial cells, and bone marrow stroma. Clinically, G-CSF aids in speeding up hematopoietic recovery following bone marrow transplantation. Notably, both human and murine G-CSF show reactivity across species. The recombinant Human G-CSF is a 18.7 kDa protein comprising 174 amino acid residues. . Amino acid sequence: TPLGPASSLP QSFLLKCLEQ VRKIQGDGAA LQEKLCATYK LCHPEELVLL GHSLGIPWAP LSSCPSQALQ LAGCLSQLHS GLFLYQGLLQ ALEGISPELG PTLDTLQLDV ADFATTIWQQ MEELGMAPAL QPTQGAMPAF ASAFQRRAGG VLVASHLQSF LEVSYRVLRH LAQP. Endotoxin concentration: <0.1 EU/µg. Activity: Determined by its ability to stimulate the proliferation of mouse NFS-60 cells. The expected ED50 is = 0.1 ng/ml, corresponding to a specific activity of > 1 x 10^7 units/mg. Contains no preservative. Protein function: Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes. [The UniProt Consortium]