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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Fibroblast growth factor 1 (FGF1), also known as acidic FGF (AFGF), is a signaling polypeptide... more
Product information "FGF1 (human, recombinant)"
Fibroblast growth factor 1 (FGF1), also known as acidic FGF (AFGF), is a signaling polypeptide and member of the FGF family with roles in cell growth, proliferation, development, and survival, as well as osteogenesis and adipogenesis. Unlike other FGFs, FGF1 lacks an N-terminal signaling peptide and is secreted via a non-canonical pathway as part of a multi-protein complex. FGF1 binds to FGF receptors at the cell surface to stimulate intracellular signaling pathways such as PKC/PLCgamma, PI3K/Akt/mTOR, and ERK/MAPK, but can also be translocated across the cell membrane to localize in both the cytosol and nucleus. FGF1 induces osteogenic differentiation of bone marrow mesenchymal stem cells and increases the number of osteoblasts in early stages of bone repair. Exogenous administration of FGF1 normalizes blood glucose levels in diabetic ob/ob and db/db mice and a mouse model of diet-induced obesity. Cayman's FGF1 (human, recombinant) protein can be used for cell-based assays. This protein consists of 141 amino acids and has a calculated molecular weight of 16 kDa.Synonyms: Acidic Fibroblast Growth Factor, Acidic FGF, AFGF, Endothelial Cell Growth Factor, FGFA, FGF-alpha, Fibroblast Growth Factor 1, HBGF-1, Heparin-binding Growth Factor 1. Purity: >95% estimated by SDS-PAGE. Source: Active recombinant human FGF1 expressed in E. coli. Amino Acids: 16-155. MW: 16 kDa. Formulation: (Request formulation change), Lyophilized from sterile PBS, pH 7.4, with 22.5% Trehalose. UniProt Accession #: P05230.
Keywords: | FGF1, FGFA, aFGF, ECGF, aFGF, ECGF, FGF-1, FGF-1, HBGF-1, HBGF-1, Fibroblast growth factor 1, Fibroblast growth factor 1, Endothelial cell growth factor, Endothelial cell growth factor, Acidic fibroblast growth factor, Heparin-binding growth factor 1, Aci |
Supplier: | Cayman Chemical |
Supplier-Nr: | 33734 |
Properties
Application: | Active, cell culture |
Conjugate: | No |
Host: | E.coli |
Species reactivity: | human |
Purity: | >95% estimated by SDS-PAGE |
Format: | Lyophilized |
Database Information
KEGG ID : | K18496 | Matching products |
UniProt ID : | P05230 | Matching products |
Gene ID | GeneID 2246 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | -80°C (International: -80°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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