FGF-8 (human), animal free recombinant

FGF-8 (FGF-8b) is a growth factor within the FGF family that binds to heparin. Proteins in this family are crucial for prenatal development, postnatal growth, and the regeneration of various tissues by stimulating cellular proliferation and differentiation. There are four known alternatively spliced forms of FGF-8: FGF-8A, FGF-8B, FGF-8E, and FGF-8F. Human and murine FGF-8A and FGF-8B are identical, while human and mouse FGF-8E and FGF-8F share 98% identity. FGF-8 targets mammary carcinoma cells and other cells expressing FGF receptors. Recombinant Human/Murine FGF-8 (FGF-8b) is a protein weighing 22.5 kDa and composed of 194 amino acid residues. Product Specifications Species Human Published Species Human, Mouse Expression System E.Coli Amino Acid Sequence MQVTVQSSPN FTQHVREQSL VTDQLSRRLI RTYQLYSRTS GKHVQVLANK RINAMAEDGD PFAKLIVETD TFGSRVRVRG AETGLYICMN KKGKLIAKSN GKGKDCVFTE IVLENNYTAL QNAKYEGWYM AFTRKGRPRK GSKTRQHQRE VHFMKRLPRG HHTTEQSLRF EFLNYPPFTR SLRGSQRTWA PEPR Molecular Weight 22.5 kDa Class Recombinant Type Protein Purity > 98% by SDS-PAGE gel and HPLC analyses Endotoxin concentration <0.1 EU/µg Activity Determined by a cell proliferation assay using balb/c 3T3 cells. The expected ED50 for this effect is 2.0-4.0 ng/ml. Form Lyophilized Contains No Preservative CAUTION For Research Use Only. Not for use in diagnostic procedures.Protein function: Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system (PubMed:16384934, PubMed:16597617, PubMed:8663044). Plays a role in neurite outgrowth in hippocampal cells (PubMed:21576111). [The UniProt Consortium]