FGF-21 (mouse) (rec.)

FGF-21 (mouse) (rec.)
%
Item number Size Datasheet Manual SDS Delivery time Quantity Discount Price
AG-40B-0143-C010 10 µg -

3 - 9 business days*

10 %
215.00€
193.50€
AG-40B-0143-3010 30 µg (3 x 10 µg) -

3 - 9 business days*

10 %
429.00€
386.10€
 
3 x 10 µg. Mouse FGF-21 (aa 29-210) is fused at the N-terminus to a FLAG(R)-tag. FLAG is a... more
Product information "FGF-21 (mouse) (rec.)"
3 x 10 µg. Mouse FGF-21 (aa 29-210) is fused at the N-terminus to a FLAG(R)-tag. FLAG is a registered trademark of Sigma-Aldrich Co. Lyophilized. Contains PBS. Protein function: Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity probably requires the presence of KLB. [The UniProt Consortium] Fibroblast growth factor 21 (FGF-21) is a member of the fibroblast growth factor family and has been identified as an important regulator of energy metabolism connecting nutrition, growth, reproduction and longevity. FGF-21 lacks the heparin-binding domain of most FGF proteins, allowing its secretion. FGF-21 is abundantly expressed in adipose tissues, liver and pancreas. In adipose tissue, FGF-21 promotes glucose uptake and oxidation and in liver it replenishes on fasting the tissues with fuel on low nutritional supply. It also induces lipolysis and ketogenesis. FGF-21 acts through FGF receptors (FGFR) associated with the auxiliary protein beta-Klotho. Recently, FGF-21 has been reported to interact directly with the brain circadian clock to coordinate activity and reproduction as part of the adaptation to fasting. Due to its multiple functions of normalizing glucose, lipid and energy homeostasis, FGF-21 represents an attractive novel therapy for type 2 diabetes mellitus and obesity.
Keywords: Fgf21, FGF-21, Fibroblast growth factor 21
Supplier: AdipoGen Life Sciences
Supplier-Nr: AG-40B-0143

Properties

Application: Bioassays
Conjugate: No
Host: Human cells
Species reactivity: mouse
MW: 24 kD
Format: Lyophilized

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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