Endocrine Gland Vascular Endothelial Growth Factor (EG-VEGF) Recombinant (Human)

Recombinant human endocrine gland vascular endothelial growth factor recombinant (EG-VEGF), also known as prokinecticin-1, full length of mature protein, encompassing amino acids 20-105. This construct is tag-free and was affinity purified. This factor is identical with prokineticin-1 and is a member of the AVIT protein family. Expression of human EG-VEGF messenger RNA is restricted to the steroidogenic glands, ovary, testis, adrenal and placenta and is often complementary to the expression of VEGF. EG-VEGF has been identified as a mitogen specific for the endothelium of steroidogenic glands. EG-VEGF resembles VEGF in that it causes extensive angiogenesis and cyst formation when delivered in the ovary. EG-VEGF differs from VEGF in that it does not promote angiogenesis in the cornea or skeletal muscle. Two receptors (the G-protein-coupled receptor ZAQ and the G-protein-coupled receptor I5E) have been characterized, these receptors are expressed in gastrointestinal organs, endocrine glands and other tissues.