CD40 Ligand (CD40LG) (TNFSF5), rat recombinant (rraCD40LG)

Produced in Yeast. Amino acid sequence: MQKGDEDPQI AAHVVSEANS NAASVLQWAK KGYYTMKSNL VVLENGRQLT VKREGLYYVY TQVTFCSNRE PLSQRPFIVS LWLKPSSGSE RILLRAANTH SSSKLCEQQS IHLGGVFELQ AGASVFVNVT EASQVIHGIG FSSFGLLKL (149). Protein function: Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation. Induces the activation of NF-kappa-B. Induces the activation of kinases MAPK8 and PAK2 in T-cells. Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4. Involved in immunoglobulin class switching. [The UniProt Consortium]