CCL22 (human):Fc (human) (rec.)

The extracellular domain of human CCL22 (aa 25-93) is fused at the C-terminus to the Fc portion of human IgG1. CCL22, also named stimulated T cell chemotactic protein (STCP1), is a CC chemokine initially isolated from clones of monocyte-derived macrophages and binds to the receptor CCR4. Human CCL22 is highly expressed in macrophage and in monocyte-derived dendritic cells and thymus. It is also found in lymph node, appendix, activated monocytes, resting and activated macrophages. May play a role in the trafficking of activated/effector T-lymphocytes to inflammatory sites and other aspects of activated T-lymphocyte physiology. CCL22 has been shown to induce chemotaxis or Ca2 mobilization in dendritic cells, IL-2 activated NK cells and activated T lymphocytes.